List of Posters
Posters on Main Workshop Day1 (Tuesday June 20, 2023, 2023)
Ligand-Binding PK, Biomarkers and Biotherapeutics Immunogenicity Assays
Day1-P01: "ELISA based assay for Quantitation of an ADC drug PYX-201 in rat and monkey plasma "
Poster Presenter: Alvin Evans (KCAS Biomarker and Bioanalytical Services, Olathe, Kansas, United States)
Co-Authors: Nathan Johnson1, Feng Yin2, Chris DeCiantis1, Jose Bernal1, Hellen Tanui1, Jan Pinkas2, Biplab Das2, Frank Wang2, Aniruddha Amrite2, Diana Adhikari2, Jack Sikora2, Mike Dyszel2, Shawn Harriman2, Rebecca Wates1, Cheikh Kane1
1KCAS Bioanalytical and Biomarker Services, 10830 South Clay Blair Boulevard, Olathe, KS 66061, USA
2Pyxis Oncology, Inc., 150 Cambridgepark Drive, Cambridge, MA 02140, USA
Day1-P02: "Optimization of Calibration Curve Design via Hybrid In Silico/In Vitro Analysis of Serial and Non-Serial Dilution Schemes"
Poster Presenter: Jack Rogers (KCAS Biosciences, Olathe, Kansas, United States)
Co-Authors: Jessie Allen, Josue Bernal, Lauren Stevens, Chris DeCiantis, Rebecca Wates, Cheikh Kane
KCAS Biosciences
Day1-P03: "Development of a Robust and Sensitive Enzyme-Linked Immunosorbent Assay (ELISA) for Quantitation of OPA1 Protein in Retina from Non-Human Primate
"
Poster Presenter: Deirdre Slate (Stoke therapeutics, Bedford, Massachusetts, United States)
Co-Authors: Deirdre Slate, Shobha Ravipaty, Meena
Stoke Therapeutics
Day1-P04: "Multiple Platform Verification of Anomalous Immunoassay Results in a Human Transgenic Mouse Model"
Poster Presenter: Katherine Lundeen (Takeda Development Center Americas, Inc. San Diego, CA, San Diego, California, United States)
Co-Authors: Katherine Lundeen, Faizan Zubair, Mostafa Khan, Paul Rolzin, Nicola Broadbent, Fernanda Camargo, Andrea Green, Mike Zientek
Takeda Development Center Americas, Inc.
Day1-P05: "Life Cycle Management of Pharmacokinetics Assay for the Quantification of Monoclonal Antibody 03 (Ab03) in Human Serum"
Poster Presenter: Li Liu (Teva Branded Pharmaceutical Products R&D, Inc., , West Chester, Pennsylvania, United States)
Co-Authors: Li Liu, Steven Weiner, Erxin Li, Julie Wangsa, Michele Rasamoelisolo, and Shawn Li
Teva Branded Pharmaceutical Products R&D, Inc., West Chester, PA 19380, USA
Day1-P06: "Development and Validation of Pharmacokinetic (PK) Assay for a Biparatopic Antibody"
Poster Presenter: Joyce Huang (Eurofins Bioanalytical Services, St Charles, Missouri, United States)
Co-Authors: Y. Joyce Huang [1], Erwin Bankston Jr [1], Brian Feldman [1], Yvonne Liu [2], Harshad S. Ugamraj [2], Kevin Dang [2], Ute Schellenberger [2], Andrew Martens [1], Ruqi Wang [1], Erik Jerks [1]
[1] Eurofins Bioanalytical Services, St. Charles, Missouri, USA
[2] Teneobio, Newark, California, USA
Day1-P07: "Bioanalytical Challenges in Measuring PEG Across Multiple PEGylated Molecules"
Poster Presenter: Nancy Yu (Genentech, Inc, South San Francisco, California, United States)
Co-Authors: Nancy Yu1, Vincent Chang2, Mehraban Khosraviani1, Emma Liu1
1 BioAnalytical Sciences, Genentech, South San Francisco, CA, USA 2 Clinical Pharmacology, Gilead, Foster City, CA, USA
Day1-P08: "Attachment Issues?...Measuring Drug in the Presence of a Reversal Agent"
Poster Presenter: Liann Chao (Regeneron, Tarrytown, New York, United States)
Co-Authors: Joseph Schoen, Joshua Zylstra Christine Grimaldi and Giane Sumner
Regeneron
Day1-P09: "Design and validation of a bioanalytical method to support a clinical pharmacokinetic study involving the use of multiple lots of the biological therapeutic drug "
Poster Presenter: Houtan Moshiri (Altasciences Company Inc, Laval, Quebec, Canada)
Co-Authors: Houtan Moshiri, Vasken Parsekhian, and Danielle Salha
Altasciences
Day1-P10: "Comparison of exploratory biomarker concentrations interpolated from freshly prepared standard curve and master curve in ligand binding assays"
Poster Presenter: Krishna Midde (PPD, richmond, Virginia, United States)
Co-Authors: Joseph Kimball, Sheela Karunanithi, Hema Kothari
ICD-Biomarkers, PPD part of Thermo Fisher Scientific
Day1-P11: "Bioanalytical Assessment of Four Commercial Methods for the Simultaneous Quantitation of CD163 and IL-6"
Poster Presenter: Julio Luna (Alexion AstraZeneca Rare Disease, New Haven, Connecticut, United States)
Co-Authors: Elena Tarabra, Tobin Cammett
Alexion AstraZeneca Rare Disease
Day1-P12: "A Streamlined Strategy for Bioanalytical Qualification of Biomarker Assays in a Rare Matrix"
Poster Presenter: Jennifer Getz (Genentech, South San Francisco, California, United States)
Co-Authors: Trung Nguy, Randall Dere, Mauricio Maia
Genentech
Day1-P13: "Partial Method Validation Of Biomarker Assays To Determine Adrenocorticotropic Hormone (ACTH) Concentrations In Rat And Canine Serum In Support Of Pre-Clinical Endocrinology Drug Development
"
Poster Presenter: Michael Sonnenfelt (QPS, Newark, Delaware, United States)
Co-Authors: Taylor Blizzazrd(1), Kim Annis(1), Barry Jones(2), Rosa Luo(2), Susan Zondlo(1), Jian Wang(2)
(1) QPS, Newark, DE
(2) Crinetics Pharmaceuticals, San Diego, CA
Day1-P14: "Approaches to Designing Drug Tolerant Biomarker Assays"
Poster Presenter: Sean McAfee (Regeneron Pharmaceuticals, Inc., Tarrytown, New York, United States)
Co-Authors: Sean McAfee*, Emily Ressegue*, Joshua Zylstra, Christine Grimaldi and Giane Sumner
*These authors contributed equally.
Regeneron Pharmaceuticals, Inc.
Day1-P15: "Screening Signal-to-Noise as an Alternative to Titer for Characterization of the Magnitude of Anti-Drug Antibody Response"
Poster Presenter: Kayla Santiago (Regeneron, Tarrytown, New York, United States)
Co-Authors: Aimen Shaadab, Jenny L. Valentine, Ching-Ha Lai, Lisa DeStefano, Albert Torri, Matthew D. Andisik, Michael A. Partridge
Day1-P16: "Implementation of a nonclinical generic ADA assay to streamline immunogenicity assessment"
Poster Presenter: Alejandro Rodriguez (Genentech, South San Francisco, California, United States)
Co-Authors: Alejandro Rodriguez, Gizette Sperinde, Rebecca Elliott, Saloumeh Fischer
Genentech
Day1-P17: "Procedural Alterations to Reduce High Positive Control Precision in Anti-Drug Antibody Immunogenicity Assays"
Poster Presenter: Mark Ainge (PPD, part of Thermo Fisher Scientific, Richmond, Virginia, United States)
Co-Authors: Mark Ainge, Janine Micheli PhD, Elizabeth Elliott, Matthew Stinchcomb, Kelli Phillips PhD, Megan San Pietro, Austin Greenhill
PPD, part of Thermo Fisher Scientific
Day1-P18: "Maximizing our efficiency with Gyrolab platform by combining sensitive PK and drug tolerant ADA assays in support of a clinical study for a multispecific mAb"
Poster Presenter: Nathalie Mace (SANOFI, CHILLY-MAZARIN, Other/None, France)
Co-Authors: Nathalie Mace, Audrey Abgrall, Stephanie Meyfroot, Yannick Gueguen, Joelle Mailleau, Marie-Helene Pascual
Day1-P19: "Immunogenicity Assessment Strategy for an Fc Fusion Protein Therapeutic"
Poster Presenter: Timothy Myers (BioAgilytix Labs, Durham, North Carolina, United States)
Co-Authors: Jennifer Kutek, Ashley Summerville, Chris Carlin, Amanda Hays, Michelle Miller, Robert Nelson, Lynn Kamen, Jim McNally
BioAgilytix Labs
Day1-P20: "Detection of Neutralizing Antibody (NAb) Against One Arm of a Bispecific Antibody is Affected by NAb Against Other Arm"
Poster Presenter: Michael Luong (Pfizer, Andover, Massachusetts, United States)
Co-Authors: Ying Wang, Pawel Dominik, Christopher Lepsy
Worldwide Research, Development and Medical, Pfizer, Inc.
Day1-P21: "Multiple Strategies for Mitigating Immunogenicity Assay Interferences"
Poster Presenter: Lisette Fred Lucena (Immunologix Laboratories, Tampa, Florida, United States)
Co-Authors: Lisette M. Fred Lucena, Kayla J. Boccio, Julia L. Allen, Ryan A. Sweet, Alexandra Sullivan, Adam A. Gentile, Lauren F. Stevenson
Immunologix Laboratories
Day1-P22: "A competitive ligand-binding assay for the detection of neutralizing antibodies against XTMAB-16"
Poster Presenter: Lili Liao (Frontage Laboratories Inc., Exton, Pennsylvania, United States)
Co-Authors: Lili Liao, Yongzhong Zhao, Wensheng Yang, Kenneth Swart, Tom Matthews, Nan Zhang
Frontage Laboratories Inc. and Xentria Inc.
Day1-P23: "Development of Neutralizing Antibody Assays with High Drug-Tolerance, Low Free Target Interference and High Sensitivity for Immunogenicity Assessments of Therapeutic mAbs"
Poster Presenter: Keguan Chen (GSK, Exton, Pennsylvania, United States)
Co-Authors: Keguan Chen, Yong Jiang, George Gunn and Erik Meyer
GSK
Day1-P24: "Immunogenicity Assessment of Mirvetuximab Soravtansine in Patients with Folate Receptor-α Positive Ovarian Cancer"
Poster Presenter: Fengying Zhu (Immunogen, Waltham, Massachusetts, United States)
Co-Authors: Fengying Zhu1, Tammy Sanders2, Rebecca Carmean2, Janine Micheli2, Yaping Tu1, Callum M. Sloss1, Michael Method1, Eric H. Westin1, Anna Berkenblit1
1ImmunoGen, Waltham, MA, USA
2PPD, Part of Thermo Fisher Scientific, Richmond VA, USA
Day1-P25: "Assessment of Various Assay Formats for the Detection of Anti-Drug Antibodies to Zinpentraxin Alfa"
Poster Presenter: Xiaoyun Yang (Genentech, South San Francisco, California, United States)
Co-Authors: Xiaoyun Yang, Ketevan Siradze, Gizette Sperinde, Audrey Arjomandi, Saloumeh Fischer
BioAnalytical Sciences, Genentech, Inc.1 DNA Way, South San Francisco, CA 94080, USA
Day1-P26: "Development of a novel neutralizing antibody assay for a multi-domain ligand trap"
Poster Presenter: Papa Drame (Keros Therapeutics, Lexington, Massachusetts, United States)
Co-Authors: Papa M. Drame, Olivia Sierra, Dina Abramovich, Claire Tseng, Francis Wolenski, and Jinsong Yang
Research and Development, Keros Therapeutics
Day1-P27: "A new statistical algorithm to set titration assay cut point for quantitation of anti-drug antibody"
Poster Presenter: Charles Tan (Pfizer Inc., Lower Gwynedd, Pennsylvania, United States)
Co-Authors:
Posters on Main Workshop Day2 (Wednesday June 21, 2023, 2023)
Cell-Based, Flow Cytometry, PCR, NGS Assays and Gene/Cell Therapy and Vaccine Immunogenicity
Day2-P01: "Revolutionizing Bioanalysis through Automation: Overcoming Challenges and Unlocking Potential"
Poster Presenter: Connor Kenney (Worldwide Clinical Trials, Austin, Texas, United States)
Co-Authors: Connor Kenney, William Banks
Worldwide Clinical Trials
Hamilton Automation LLC
Day2-P02: "How minor blood collection differences can cause major issues for analytical methods"
Poster Presenter: Martin Roberge (CIRION BioPharma Research inc., Laval, Quebec, Canada)
Co-Authors: Martin Roberge, Sylvie Gelinas, Jennyfer Lacasse, Justine Belanger, Andre Forte, Mathilde Yu
CIRION BioPharma Research Inc.
Day2-P03: "Calibration-free method for quantitative analysis of target level on cells based on the kinetics of antibody binding"
Poster Presenter: Daniel Doty (Pfizer, Arlington, Massachusetts, United States)
Co-Authors: Daniel Doty, Mahua Roy, Peter Struss, Jatin Narula, Lindsay E. King, Polina Goihberg
Pfizer
Day2-P04: "Advancing ELISpot Results: The Importance of Sample Quality"
Poster Presenter: Juliane Ober-Blöbaum (BioAgilytix Europe, Hamburg, Other/None, Germany)
Co-Authors: Aaron Ochel
BioAgilytix Europe
Lademannbogen 10
22339 Hamburg
Germany
aaron.ochel@bioagilytix.de
Day2-P05: "Immune profiling by flow cytometry: Development and Validation of a 22-marker, 19-color ex vivo stimulation and intracellular cytokine staining (ICS) assay to assess vaccine induced immune responses in human vaccine trials"
Poster Presenter: Shannon McGrath (Moderna, Norwood, Massachusetts, United States)
Co-Authors: Hsiaohsuan Kuo, Md Hasan, Jodi Moore, Qi Wu, Alejandra Perez, Lisa Ramos-Rodriguez, Liam Murphy, Paul C. Trampont
Moderna, Inc.
Day2-P06: "Rapid thawing of PBMCs: a novel approach to preparing cryopreserved cells for downstream analysis"
Poster Presenter: Stephanie Fausett (ICON Bioanalytical Laboratories, Lenexa, Kansas, United States)
Co-Authors: Long Nguyen, Kari Cheatum, Torrie Cross, Dalton Mantia, Steven Pelot
Day2-P07: "A High-parameter T Cell Panel on a BD Symphony A5 and Validated in Alignment with the CLSI H62 Guideline"
Poster Presenter: Virginia Litwin (Eurofins BioPharma Services, Bromont, Quebec, Canada)
Co-Authors: Kristen Mickey1, Thomas Beadnell1, Jordyn Westergaard1, Virginia Litwin2
1Eurofins Viracor BioPharma, Lenexa, Kansas, USA
2Eurofins BioPharma Services, Montréal, Québec, Canada
Day2-P08: "FLOW Cytometry as Second Control Level to Predict Efficacy in Functional Immune Effector Cell Assays"
Poster Presenter: Aaron Ochel (BioAgilytix Europe, Hamburg, Other/None, Germany)
Co-Authors: Juliane Ober-Bloebaum
Dr. Juliane Ober-Bloebaum
Associate Director Cellular Immunology
BioAgilytix Europe
Lademannbogen 10
22339 Hamburg
Germany
juliane.ober-bloebaum@bioagilytix.de
Day2-P09: "Impact of Endotoxin Contamination in Blood Collection Tubes on Downstream Biomarker Assay Measurements"
Poster Presenter: Ping Cheng Yi (Gilead Sciences, Foster City, California, United States)
Co-Authors: 1. Ping Cheng Yi
2. Julie Lin
3. Calvin Chang
4. Sam Kim
5. Audrey Goddard
Gilead Sciences
Day2-P10: "A longitudinal study to evaluate the impact of processing time on PBMC stability, viability composition and function for immunology studies in a multicentre clinical trials setting."
Poster Presenter: Kurt Sales (Agilex Biolabs Pty Ltd, Adelaide, Other/None, Australia)
Co-Authors: Kurt J. Sales; Patrick Hughes; Chris Mavrangelos
Agilex Biolabs Pty Ltd
Day2-P11: "Development of in-vitro potency assays to evaluate early activation, Granzyme B secretion, and cytotoxicity of CAR-T cells."
Poster Presenter: Jiu Jiang (Pharmaron (Exton) Lab Services LLC, Exton, Pennsylvania, United States)
Co-Authors: Lisa Yu, Imelda Mema, Rachana Patel, Wayne Zhou, Sicco Popma, and Sid Bhoopathy
Pharmaron (Exton) Lab Services LLC
Day2-P12: "Quantitation of Replication Competent Retroviruses and Replication Competent Lentiviruses using Validated Quantitative Real Time PCR Assays "
Poster Presenter: Dallas Jones (Eurofins Viracor, lenexa, Kansas, United States)
Co-Authors: Dallas Jones, Manisha Diaz, Laura Delozier, Xiaoling Shen, Pamela Douglass, Amy Lee, Luther Grulkle, Ashley Huskey, Andrew Brewer, Dan Jobes, Marissa Villarreal, Megan Dalton, Madison Hendrickson, Kimberly Murray, Aliyah Collins, Emmitt Wheelan, Anthonio Johnson, Elijah Ybarra, Megan Allinson
Eurofins Viracor Biopharma, Eurofins Pharma Bioanalytical Services
Day2-P13: "Fit-for-purpose Validation of a Model Gene Therapy Biodistribution Assay for AVGN7 using ddPCR"
Poster Presenter: Agostinho Rocha (Smithers , Ewing, New Jersey, United States)
Co-Authors: Buel D. Rodgers (a), Sarah K. Herring (b), Joyce Chen (c) and Agostinho G. Rocha (c)
a. AAVogen, Rockville, MD 20850
b. Latham BioPharm Group, Elkridge, MD 21075
c. Smithers Pharmaceutical Development Services, Ewing, NJ 08628
Day2-P14: "Best Practices for the Concordance of qPCR and dPCR Assays"
Poster Presenter: Timothy Lochmann (PPD, Richmond, Virginia, United States)
Co-Authors: Luis Ramirez, Analise Presley, Emma Rademacher, Hanzhang Xia, Daniel Heisey, Sapna Murukesan, Abigail Cross, Amy Lavelle
PPD
Day2-P15: "Clinical Bioanalysis Strategy for AAV Gene Therapy Drugs"
Poster Presenter: Zhiyan Li (Shanghai Xihua Scientific Co., Ltd., Shanghai, Other/None, China)
Co-Authors: Zhiyan Li (a)*, Weihua Gu (a), Liangxia Wei (a), Haitang Wu (a), Zixian Jiang (a), Qiu Ren (a)
(a) Shanghai Xihua Scientific Co.,Ltd.
*Corresponding author. Shanghai Xihua Scientific Co.,Ltd., Building 6, Lane 118, Furonghua Road, Pudong New Area, Shanghai, China.
E-mail address: zhiyan_li@xihuasci.com.
Day2-P16: "Digital PCR bioanalysis: technical considerations for the support biodistribution studies"
Poster Presenter: Olaf Bjornstal (Pfizer, Andover, Massachusetts, United States)
Co-Authors: Beth Leary
Alison Joyce
Pfizer
Day2-P17: "Multi-tissue Matrix Extraction Optimization and Analysis for Biodistribution PCR Assay Development"
Poster Presenter: Jacqueline Murphy (Janssen, Spring House, Pennsylvania, United States)
Co-Authors: Jacqueline Murphy, Kate Herr, Shannon McKee, Venkata Vepachedu, Tong-Yuan Yang
Janssen
Day2-P18: "Significant Technical Breakthrough of qPCR Method with Consistent LLOQ Sensitivity of 8 copies / µg DNA in a 20 µL Reaction"
Poster Presenter: Bin Xu (Accurant Biotech, Cranbury, New Jersey, United States)
Co-Authors: Xiaoyu Zhang, Xiao-Yan Cai, Dongbei Li
Accurant Biotech
Day2-P19: "Validation of a 384 gene hybridization capture-based pharmacogenomics NGS panel: sensitivity, specificity, accuracy, and reproducibility in calling star alleles for drug metabolism genes."
Poster Presenter: David Willoughby (Frontage Laboratories, Inc., Deerfield Beach, Florida, United States)
Co-Authors: Ericca Stamper, Peter Zhang, Weiming Shen, Casey Nagel, Aman Pruthi, Malkanthi Mudannayake, and David Willoughby
Day2-P20: "Quantitation of Dystrophin and Microdystrophin by A Capillary-based Western Immunoassay to support clinical trials for RGX-202, A Novel AAV8-Based Gene Therapy for Duchenne Muscular Dystrophy"
Poster Presenter: Hiren Patel (REGENXBIO, Rockville, Maryland, United States)
Co-Authors: Hiren Patel, Louis Gardner, Chris Tully, Lin Yang and Michele Fiscella.
REGENXBIO Inc., Rockville, MD 20850.
Day2-P21: "Strategies for the Development and Validation of ADA assays for LNP-based RNA Therapeutics"
Poster Presenter: Amiee Weiser (BioAgilytix Labs, Durham, North Carolina, United States)
Co-Authors: Yuri Matsomoto*, Amiee Weiser^, Yongli Gu*, Ellen Rohde*, Chris Carlin^, Natalie Telep^, Amanda Hays^, Michelle Miller^, Rob Nelson^, Jim McNally^, and Lynn Kamen^
*Verve Therapeutics
^BioAgilytix Labs
Day2-P22: "Multiplex Assay and Method Qualification Strategies for Detecting Serologic Response to Vaccine Candidates targeting SARS-CoV-2 Variants of Concern"
Poster Presenter: Yingwen Xiao (Moderna TX, Norwood, Massachusetts, United States)
Co-Authors: Samuele Bianchet-David, Bhaskar Sarmah, Liang Zhu, and Paul C. Trampont
Moderna TX
Day2-P23: "Selection of a high-throughput screening tool of COVID-19 convalescent plasma for plasma-derived medicinal products"
Poster Presenter: Ji Ah Noh (GC Pharma, Yong in , Other/None, Korea, Republic of)
Co-Authors: Lil-li Lee1), Shi-nea Kwon1), Kyoung-chul Shin1), Ho-sun Park2), Man-seong Park3)
1) GC Pharma
2) Yeungnam University Medical Center
3) Korea University College of Medicine
Day2-P24: "Method Development and Validation of Serologic Total IgG and Neutralizing IgG Assays for Clinical Development of a 14-valent Human Papillomavirus Vaccine Using Luminex"
Poster Presenter: Weihua Gu (Shanghai Xihua Scientific Co., Ltd., Shanghai, Other/None, China)
Co-Authors: Hong Li(a), Xinting Zhang(a), Yuxing Zhuang(a), Jiajia Chen(a), Weihua Gu(a) *, Jia Liu(a), Xiaohang Shen(a), Xiao Zhang(b), Dan Meng(b), Xuefeng Li(b), Liangzhi Xie(b)
(a) Shanghai Xihua Scientific Co.,Ltd.
(b) Beijing Engineering Research Center of Protein and Antibody, Sinocelltech Ltd., Beijing 100176, China
*Corresponding author. Shanghai Xihua Scientific Co.,Ltd., Building 6, Lane 118, Furonghua Road, Pudong New Area, Shanghai, China.
E-mail address: weihua_gu@xihuasci.com.
Day2-P25: "Preparation and biochemical characterization of labeled AAVs for immunogenicity assays
"
Poster Presenter: Byung Chul Kim (Regeneron , Tarrytown , New York, United States)
Co-Authors: Alyssa Petersen, Elif Karayusuf, Joshua Zylstra, Christine Grimaldi, Giane Sumner, Kun Lu, Nisha Palackal, Erica Pyles
Day2-P26: "Critical insights to method qualification for virus neutralization and binding assays to vaccine-matched strains of Respiratory Syncytial Virus"
Poster Presenter: Tin Bartholomew (Moderna, Inc., Norwood, Massachusetts, United States)
Co-Authors: Tin Bartholomew, Yu Zhang, Vick Amadu, Julianna Paladino, Maggie Li, Bhaskar Sarmah, Liang Zhu, and Paul C Trampont
Moderna, Inc.
Posters on Main Workshop Day3 (Thursday June 22, 2023, 2023)
Mass Spectrometry Assays and Tissues Analysis by LBA and Critical Reagents
Day3-P01: "Epitope Specific Concentration Analysis of Recombinant Calibrators for Biomarker LBAs"
Poster Presenter: Ian Harvey (Bristol Myers Squibb, Princeton, New Jersey, United States)
Co-Authors: Devyani Bhosale, Jon Haulenbeek, Shannon Chilewski
Bristol Myers Squibb | TS&Dx | MSLPE
Day3-P02: "TITLE: Long Term Investigation of Formulation Buffers to Mitigate Stability Issues of Conjugated Critical Reagents
"
Poster Presenter: Glenn Miller (Pfizer, Andover, Massachusetts, United States)
Co-Authors: Teresa Caiazzo, Alison Joyce
Pfizer
Day3-P03: "A simple and high-throughput method for measuring tissue glycogen levels"
Poster Presenter: Jayharsh Panchal (Asklepios BioPharmaceutical, Apex, North Carolina, United States)
Co-Authors: Jayharsh Panchal, Danielle Finger, Kayla Schumate and Xiaodong Fang
Asklepios BioPharmaceutical Inc., Durham, North Carolina, USA
Day3-P04: "Tissue processing for tandem extraction of nucleic acids and protein (ELISA) for gene therapy"
Poster Presenter: Uma Karadge (Kriya Therapeutics, Durham, North Carolina, United States)
Co-Authors: William Chappell, Sydney Tickle, Christopher Lassiter, Lauren Parker, Jiewu Liu
Kriya Therapeutics
Day3-P05: "Validation of an LC-MS/MS method for quantification of heparan sulfate in serum and CSF from MPS II patients"
Poster Presenter: Min Ju Kim (GC Pharma, yongin-si, Other/None, Korea, Republic of)
Co-Authors: MinJu Kim, HyeRyung Koo, JiYeon Cheon, EunJin Choi, HeeJoo Lee, SongHyun Yang,Sujung Kim, Sinae Kwon
Day3-P06: "Bioanalytical LC-MS Strategies in the Bioanalysis of siRNA with Multiple Deamination Sites"
Poster Presenter: Xien Yu Chua (Alnylam, Cambridge, Massachusetts, United States)
Co-Authors: Lu Tan, Jing Li, Guodong Zhang
Day3-P07: "Sensitive, Reproducible and simultaneous Bioanalytical method of Isosorbide Dinitrate and its metabolites Isosorbide 2-mononitrate and Isosorbide 5-mononitrate in human matrix samples for Pharmacokinetics analysis"
Poster Presenter: Swati Guttikar (Veeda Clinical Research Ltd., Ahmedabad, Other/None, India)
Co-Authors: Jayrajsinh Chudasama, Vipul Chauhan, Swati Guttikar
Veeda clinical Research Ltd
Day3-P08: "Method Development and Validation of Nirmatrelvir and Ritonavir in Human Breast Milk Treated with Tween 20"
Poster Presenter: Haihong Shi (Pfizer Inc., Groton, Connecticut, United States)
Co-Authors: Kevin Holmes, Pilar Gonzalez, Katty Wan, Olga Kavetska
Haihong Shi: Pfizer, Groton, CT
Katty Wan: Pfizer, San Diego, CA
Olga Kavetska: Pfizer, Groton, CT
Kevin Holmes: York Bioanalytical Solutions, York, UK
Pilar Gonzalez: York Bioanalytical Solutions, York, UK
Day3-P09: "Statistical Process Control Analysis of Automated Small-Scale Labeling on Ion Metal Affinity Chromatography (IMAC) Columns"
Poster Presenter: Xiaowei Sun (Bristol Myers Squibb, Plainsboro Township, New Jersey, United States)
Co-Authors: Sanford Harty, Alphy Herrera, Alejandra Chiquillo, Christopher Gray, Nicola Moolman, Kiran Janjua, Jonathan R. Haulenbeek, Scott A. Robotham, Graham Yearwood
Bristol Myers Squibb
Day3-P10: "Improving Detection Limit of Semi-volatile Compound Phenylcrotonaldehyde in Treated Rat Whole Blood with UPLC-MS/MS Method"
Poster Presenter: Duxi Zhang (Primera Analytical Solutions Corp, Cranbury, New Jersey, United States)
Co-Authors: Qing Zhang, Kristen Lioe, Yangyang Liu, Bob Zhang, Duxi Zhang
Day3-P11: "Low-pg/mL Quantitation of Leucine-Rich Repeat Kinase 2 (LRRK2) Using LC-MS/MS in Human Cerebrospinal Fluid (CSF)"
Poster Presenter: Dylan Bennett (Neuron23, Inc., South San Francisco, California, United States)
Co-Authors: Dylan Bennett-1, Arash Rassoulpour-1, and Rahul Baghla-2
1-Neuron23, USA; 2-SCIEX, USA
Day3-P12: "Quantification of the Polydisperse Heparin Analog Dociparstat by Signature Disaccharide Analysis in the Presence of Concomitant Enoxaparin Dosing in Support of a Phase 2/3 Study in Patients with Severe COVID-19"
Poster Presenter: Brian Engel (Q2 Solutions, Indianapolis, Indiana, United States)
Co-Authors: *Co-Authors: Brian J. Engel1, Jennifer A. Vance1, Aimee L. Rinas1, Caleb A. Schmicker1, Mark J. Mullin2, John A. Dunn2
*Work performed by Vance and Rinas occurred during their tenures at 1Q2 Solutions, 7840 Innovation Blvd Indianapolis, IN 46278.
1Q2 Solutions, 7840 Innovation Blvd Indianapolis, IN 46278; 2Chimerix, 2505 Meridian Parkway, Suite 100, Durham NC 27713
Day3-P13: "Separation and Stability Impact Assessment of an Unidentified Minor Metabolite "
Poster Presenter: Brian Wane (Syneos Health, Princeton, New Jersey, United States)
Co-Authors:
Day3-P14: "Bioanalytical Method Development, Validation and Sample Analysis for Nirmatrelvir and Ritonavir in Human Saliva Treated with Tween 20"
Poster Presenter: Pilar Gonzalez (York Bioanalytical Solutions, York, Other/None, United Kingdom)
Co-Authors: Daniel Potts (daniel.potts@yorkbio.com)
Katty Wan (Xia.Wan@pfizer.com)
Haihong Shi (Haihong.Shi@pfizer.com)
Daniel Potts from York Bionalytical Solutions
Katty Wan from Pfizer
Haihong Shi from Pfizer
Day3-P15: "Determination of protoporphyrin IX levels in human plasma and brain tumor by a validated LCMS method"
Poster Presenter: Tigran Margaryan (Ivy Brain Tumor Center at Barrow Neurological Institute, Phoenix, Arizona, United States)
Co-Authors: Tigran Margaryan, William Knight, Nader Sanai, Artak Tovmasyan
Ivy Brain Tumor Center at Barrow Neurological Institute
Day3-P16: "An Ultra-Sensitive and High Throughput Assay for Quantifying mRNA Carrier (ALC-0315) in Human Plasma using UPLC-MS/MS"
Poster Presenter: Hongfang Xue (Alliance Pharma, Inc., Malvern, Pennsylvania, United States)
Co-Authors: Andy (Hongfang) Xue, Min Meng, Emily Williamson, Daniel Skrocki, and Aihua Liu
Alliance Pharma Inc., Malvern, PA, USA
Day3-P17: "Surrogate analyte and surrogate matrix approaches for the analysis of endogenous 5-HIAA and the evaluation of its stabilities in human plasma"
Poster Presenter: Jian Wang (Crinetics Pharmaceuticals, San Diego, California, United States)
Co-Authors: Joanna Zheng, Connie Zhao, Rosa Luo, Deepak Dalvie
Crinetics Pharmaceuticals
Day3-P18: "Skin Biomarker Assay Development: Challenges and Perspectives"
Poster Presenter: Jeongsup Shim (GENENTECH, SOUTH SAN FRANCISCO, California, United States)
Co-Authors: Jeongsup Shim, Jessica Chen, Meire Bremer, Wei Bu, Jason LaMar, Rachel Basile, Montserrat Carrasco-Triguero, Hao Cai, Gizette Sperinde, Rebecca N. Bauer and Saloumeh K. Fischer
Genentech
Day3-P19: "Case Study: Systematic Comparison of Different Chromatographic Techniques for Simultaneous Quantification of Oligonucleotide and its Metabolites "
Poster Presenter: David Zuluaga-Rave (Alliance Pharma, Inc., Malvern, Pennsylvania, United States)
Co-Authors: David Zuluaga, Leif Morin, Laixin Wang, Min Meng and Aihua Liu
Alliance Pharma, Inc., Malvern, PA, USA
Day3-P20: "Application of RPLC-HRMS to Critical Reagent Characterization: Monitoring of Antibody Biotin Conjugation and Intact Protein Analysis"
Poster Presenter: Yu Hui (PPD - Part of Thermo Fisher Scientific, Henrico, Virginia, United States)
Co-Authors: Yu Hui1, Moucun Yuan1, Kumar Shah1, Eric Ma1, William R. Mylott1, M. Shane Woolf1, Joe Palandra2 and Mike Baratta2
1Analytical Services Division (ASD), PPD, Part of Thermo Fisher Scientific, Richmond, VA
2Takeda Development Center Americas, Inc., Cambridge, MA
Day3-P21: "Quantitative Assessment of KRAS G12C Engagement by A Covalent Inhibitor in Tumor Biopsies Using A Highly Sensitive Targeted 2D-LC-MS/MS Approach "
Poster Presenter: Lingyao Meng (Genentech Inc., South San Francisco, California, United States)
Co-Authors:
Day3-P22: "Inception & Development of a LC-MS/MS Assay Supporting the Multiplexed Quantitation of Nine Different Human Transporter Biomarkers in Human Plasma and Urine"
Poster Presenter: Eugene Kadar (Pfizer, Groton, Connecticut, United States)
Co-Authors: Christopher L. Holliman, Manoli Vourvahis, David Rodrigues
Pfizer
Day3-P23: "Development of a LC-MS/MS method for the quantitation of urea in human plasma using surrogate matrix and hydrophilic interaction chromatography"
Poster Presenter: Bryan Parmentier (KCAS, LLC, Olathe, Kansas, United States)
Co-Authors: Anika Pippin, Bryan Sitzmann, Scott Hammers, Marsha Luna, Lawrence Goodwin
KCAS
Day3-P24: "Patient-Centric Microsampling: Bioanalytical Method Qualification and Concentration bridging For Abrocitinib in a Clinical Study"
Poster Presenter: Sakambari Tripathy (Pfizer Inc., Ann Arbor, Michigan, United States)
Co-Authors: Xia (Katty) Wan, Mohamed H. Shahin, Jennifer Winton, Amanda Mattson, Panageota Agelapolous, David Fuschetto, Bimal Malhotra, Olga Kavetska
Xia (Katty) Wan, Mohamed H. Shahin, Jennifer Winton, Olga Kavetska are from Clinical Pharmacology and Bioanalytics, Pfizer Inc., Groton, CT, USA
Amanda Mattson, Panageota Agelapolous, David Fuschetto, are from Syneos Health Clinical Laboratories, Princeton, NJ, USA
Bimal Malhotra is from Clinical Pharmacology and Bioanalytics, Pfizer Inc., New York, NY, USA
Day3-P25: "Novel Application of IC-LC/MS/MS to Establish a Robust Target Engagement Assay for Biomarker"
Poster Presenter: Elsy Philip (Boehringer Ingelheim Pharmaceuticals, Inc. , Ridgefield, Connecticut, United States)
Co-Authors: Lin Zhi Chen, David Roos, Emily Werth, Shan Jiang, James Smith
Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield CT
Day3-P26: "Bioanalytical CRO Performance Evaluation Through KPIs"
Poster Presenter: Ming Li (Alexion, AstraZeneca Rare Disease, New Haven, Connecticut, United States)
Co-Authors: Marianne Flynn, Jay Ma*, Tracey Hall, Mira Hong, Yi Su, Caitlin Boland, Mark Ma# and Ryan Pelto
*Kira Pharmaceuticals, Inc.
#Rallybio, Inc.
Day3-P27: "Bimiralizib distribution in human skin biopsies after topical administration obtained by validated quantitative mass spectrometry imaging"
Poster Presenter: Shane Karnik (Aliri, Colorado Springs, Colorado, )
Co-Authors: Raphael Legouffe1, Selinde S. Wind2, 3, Debora Schmitz-Rohmer4, Shane Karnik5, Mathieu Gaudin1, Corinne Ramos1, David Bonnel1, Robert Rissmann2,3,6
1: ALIRI, 152 rue du Dr Yersin, 59120 Loos, France
2: Centre for Human Drug Research, 2333 CL Leiden, The Netherlands
3: Department of Dermatology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands
4: PIQUR Therapeutics AG, 4057 Basel, Switzerland
5: ALIRI, 4720 Forge Rd # 108, Colorado Springs, CO 80907, USA
6: Leiden Academic Centre for Drug Research, Leiden University, 2333 CC Leiden, The Netherlands
For Poster Presenters:
- Mandatory Presenting Time:
- During both Morning Break and Afternoon Break of the Day of your Poster - at your poster to answer questions
- Mount Time:
- Tue-Thu: 7am to 7:30am
- Take-down Time:
- Tue-Wed: 5:30pm to 6:30pm
- Thu: 4:20pm right after the Afternoon Break
Note: Removing your poster before the take-down time is NOT permitted
Poster Award:
There is poster contest at WRIB each year. Presenters of 3 most outstanding posters will each recieve free registration for next WRIB Main Workshop, as well as an interview by Bioanalysis Journal team, and appearing in a speical feature report in the Bioanalysis Journal and on Bioanalysis Zone.
Poster Board Size:
The size of our poster boards is 8'X4' (8 feet wide and 4 feet high) - standard size as the ones used at most other conferences
